MovDisordV3, Main, Exploration, bibRecord, 002D63

Lower low‐density lipoprotein cholesterol levels are associated with Parkinson's disease

Identifieur interne : 002D63 ( Main/Exploration ); précédent : 002D62; suivant : 002D64

Lower low‐density lipoprotein cholesterol levels are associated with Parkinson's disease

Auteurs : Xuemei Huang [États-Unis] ; Honglei Chen [États-Unis] ; William C. Miller [États-Unis] ; Richard B. Mailman [États-Unis] ; Jennifer L. Woodard [États-Unis] ; Peter C. Chen [États-Unis] ; Dong Xiang [États-Unis] ; Richard W. Murrow [États-Unis] ; Yi-Zhe Wang [États-Unis] ; Charles Poole [États-Unis]

Source :

Movement Disorders [ 0885-3185 ] ; 2007-02-15.

RBID : ISTEX:3E1B153FFB67B36435A859DC843CB60184B7D47D

English descriptors

KwdEn :
- Aged, Case-Control Studies, Cholesterol, LDL (metabolism), Female, Humans, Male, Middle Aged, Odds Ratio, Parkinson Disease (metabolism), Parkinson's disease, apolipoprotein E, case control study, low‐density lipoprotein cholesterol, statin.
MESH :
- chemical , metabolism : Cholesterol, LDL.
- metabolism : Parkinson Disease.
- Aged, Case-Control Studies, Female, Humans, Male, Middle Aged, Odds Ratio.

Abstract

The apolipoprotein E (APOE) ε2 allele has been associated with both Parkinson's disease (PD) and lower low‐density lipoprotein cholesterol (LDL‐C). We tested the hypothesis that lower LDL‐C may be associated with PD. This case–control study used fasting lipid profiles obtained from 124 PD cases and 112 controls. The PD cases were recruited from consecutive cases presenting at our tertiary Movement Disorder Clinic, and the controls were recruited from the spouse populations of the same clinic. Multivariate odds ratios (ORs) and 95% confidence intervals (CIs) were calculated from unconditional logistic regressions, adjusting for age, gender, smoking status, and use of cholesterol‐lowering agents. Lower LDL‐C concentrations were associated with a higher occurrence of PD. Compared with participants with the highest LDL‐C (≥138 mg/dL), the OR was 2.2 (95% CI = 0.9–5.1) for participants with LDL‐C of 115 to 137, 3.5 (95% CI = 1.6–8.1) for LDL‐C of 93 to 114, and 2.6 (95% CI = 1.1–5.9) for LDL‐C of ≤ 92. Interestingly, use of either cholesterol‐lowering drugs, or statins alone, was related to lower PD occurrence. Thus, our data provide preliminary evidence that low LDL‐C may be associated with higher occurrence of PD, and/or that statin use may lower PD occurrence, either of which finding warrants further investigation. © 2007 Movement Disorder Society

Url:

DOI: 10.1002/mds.21290

Affiliations:

Le document en format XML

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<author><name sortKey="Huang, Xuemei" sort="Huang, Xuemei" uniqKey="Huang X" first="Xuemei" last="Huang">Xuemei Huang</name>
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<author><name sortKey="Chen, Honglei" sort="Chen, Honglei" uniqKey="Chen H" first="Honglei" last="Chen">Honglei Chen</name>
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<author><name sortKey="Miller, William C" sort="Miller, William C" uniqKey="Miller W" first="William C." last="Miller">William C. Miller</name>
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<author><name sortKey="Mailman, Richard B" sort="Mailman, Richard B" uniqKey="Mailman R" first="Richard B." last="Mailman">Richard B. Mailman</name>
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<author><name sortKey="Woodard, Jennifer L" sort="Woodard, Jennifer L" uniqKey="Woodard J" first="Jennifer L." last="Woodard">Jennifer L. Woodard</name>
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<author><name sortKey="Chen, Peter C" sort="Chen, Peter C" uniqKey="Chen P" first="Peter C." last="Chen">Peter C. Chen</name>
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<author><name sortKey="Xiang, Dong" sort="Xiang, Dong" uniqKey="Xiang D" first="Dong" last="Xiang">Dong Xiang</name>
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<front><div type="abstract" xml:lang="en">The apolipoprotein E (APOE) ε2 allele has been associated with both Parkinson's disease (PD) and lower low‐density lipoprotein cholesterol (LDL‐C). We tested the hypothesis that lower LDL‐C may be associated with PD. This case–control study used fasting lipid profiles obtained from 124 PD cases and 112 controls. The PD cases were recruited from consecutive cases presenting at our tertiary Movement Disorder Clinic, and the controls were recruited from the spouse populations of the same clinic. Multivariate odds ratios (ORs) and 95% confidence intervals (CIs) were calculated from unconditional logistic regressions, adjusting for age, gender, smoking status, and use of cholesterol‐lowering agents. Lower LDL‐C concentrations were associated with a higher occurrence of PD. Compared with participants with the highest LDL‐C (≥138 mg/dL), the OR was 2.2 (95% CI = 0.9–5.1) for participants with LDL‐C of 115 to 137, 3.5 (95% CI = 1.6–8.1) for LDL‐C of 93 to 114, and 2.6 (95% CI = 1.1–5.9) for LDL‐C of ≤ 92. Interestingly, use of either cholesterol‐lowering drugs, or statins alone, was related to lower PD occurrence. Thus, our data provide preliminary evidence that low LDL‐C may be associated with higher occurrence of PD, and/or that statin use may lower PD occurrence, either of which finding warrants further investigation. © 2007 Movement Disorder Society</div>
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Movement Disorders (revue)

Lower low‐density lipoprotein cholesterol levels are associated with Parkinson's disease

Lower low‐density lipoprotein cholesterol levels are associated with Parkinson's disease

Source :

English descriptors

Abstract

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Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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	Movement Disorders (revue)
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